ACTIVITY OF THE CITRIC ACID CYCLE DEHYDROGENASES UNDER THE CONDITIONS OF SEPARATE AND COMBINED ACTION OF CADMIUM CHLORIDE AND SODIUM NITRITE (4-18)

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Дата публикации статьи в журнале: 2020/03/16
Название журнала: Восточно Европейский Научный Журнал, Выпуск: 54, Том: 4, Страницы в выпуске: 4-18
Автор: Kuras L. D.
Ivano-Frankivsk, Ivano-Frankivsk National Medical University ,
Автор: Erstenyuk H. M.
Ivano-Frankivsk, Ivano-Frankivsk National Medical University , Doctor of Biological Sciences
Анотация: Due to the regulatory reactions of high-energy processes in the cell, in particular the citric acid cycle, different types and structures of xenobiotics act. To date, the mechanisms of separate and combined effects of cadmium and nitrites on energy metabolism remain insufficy understood. In this regard, studies of Krebs cycle enzymes under the conditions of cadmium, nitrite and cadmium-nitrite intoxication in the brain, tissues of the myocardium and liver of experimental animals (rats) are relevant. The intoxication was modeled as follows: cadmium chloride was administered intramuscularly, sodium nitrite was administered with drinking water at a dose of 1/10 LD50 once daily for 10 days. Sampling was performed after decapitation under thiopental anesthesia at 1-, 14-, 28-days after the completion of the toxicant administration. The results obtained indicate that the activity of succinate dehydrogenase increased throughout the study period in all organs of experimental animals studied by us under the conditions of separate and combined action of cadmium chloride and sodium nitrite. In the brain and liver of all our studies, a decrease in isocitrate dehydrogenase activity was observed throughout the observation period.
Ключевые слова: energy metabolism   cadmium chloride   sodium nitrite   alpha-ketoglutarate dehydrogenase   isocitrate dehydrogenase   succinate dehydrogenase   malate dehydrogenase   malate dehydrogenase  
Данные для цитирования: Kuras L. D. , Erstenyuk H. M. , . ACTIVITY OF THE CITRIC ACID CYCLE DEHYDROGENASES UNDER THE CONDITIONS OF SEPARATE AND COMBINED ACTION OF CADMIUM CHLORIDE AND SODIUM NITRITE (4-18). Восточно Европейский Научный Журнал. Биологические науки. 2020/03/16; 54(4):4-18.

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