BIOCHEMICAL AND HISTOLOGICAL ANALYSIS OF RATS TREATED WITH VERAPAMIL OVERDOSE AND RESUSCITATED WITH LIPID EMULSION (4-8)

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Дата публикации статьи в журнале: 2020/11/18
Название журнала: Восточно Европейский Научный Журнал, Выпуск: 62, Том: 1, Страницы в выпуске: 4-8
Автор: Kehayova G.K.
Varna, Bulgaria , Medical University , Doctor of Toxicology Assistant professor in the Department of Pharmacology, Toxicology and Pharmacotherapy
Автор: Zlateva Sn.Z.
Varna, Bulgaria , Military Medical Academy , Professor of Toxicology
Автор: Zgurova N.T.
Varna, Bulgaria , Medical University , Doctor of Pathology and Cytopathology, Assistant professor
Анотация: Since 2008, lipid emulsions have been used successfully as part of standard therapy for acute lipophilic drug intoxications at a bolus dose of 1.5 ml/kg lipid emulsion 20% for one minute, followed by an infusion of 0.25 ml/kg/min for 20 -60 minutes. The high dose of lipid emulsion carries a risk of serious side effects, which is why many doctors are afraid to use it, despite reports of its positive effect as an antidote. The study demonstrated the efficacy and safety of lipid emulsion administered as an antidote at the recommended and 7-fold higher dose in acute intoxication of rats with Verapamil. 100% survival was observed in rats treated with different doses of lipid emulsion. The high dose of lipid emulsion 10 ml/kg shows greater efficiency in terms of cardioprotection. Lipid emulsion at doses of 1.5 ml/kg and 10 ml/kg are safe in terms of fat metabolism, liver and kidney parameters, proven by laboratory and histological analysis.
Ключевые слова: lipid emulsion   Verapamil   rats  
Данные для цитирования: Kehayova G.K. , Zlateva Sn.Z. , Zgurova N.T. . BIOCHEMICAL AND HISTOLOGICAL ANALYSIS OF RATS TREATED WITH VERAPAMIL OVERDOSE AND RESUSCITATED WITH LIPID EMULSION (4-8). Восточно Европейский Научный Журнал. Биологические науки. 2020/11/18; 62(1):4-8.

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