FUNCTIONAL ANALYSIS OF EXPERIMENTAL DATA IN THE FIELD OF MODERN RESEARCHES OF NEUTRAL MACROCYCLIC ANTIMYCOTIC FILIPIN.

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Название журнала: Восточно Европейский Научный Журнал, Выпуск: , Том: , Страницы в выпуске: -
Автор: Baghirova Arifa. Institute of Botany, Azerbaijan National Academy of Sciences
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Анотация: Summary. Biological, physical and chemical properties of macrocyclic compounds based on the researches of membrane activity are studied. So all these substances have antifungal properties and apply in the practical medicine that needs their detail research. They have names of polyene antibiotics (PA) because their chemical formula has certain number (n) conjugated double bonds( 4-7 ones). Among them electrically neutral pentaen antimycotic (5 double bonds) PA-filipin takes special place. Previous experiments of filipin fix disrupt of cell membrane in the presence of this antibiotic. Nevertheless it is possible to find the certain concentration of filipin for increase of conductivity, definition of selectivity and single ionic filipin channels and hybrid ionic channels nystatin-filipin and amphotericin- filipin. So it is confirmed filipin-sterol interaction and formation of filipin-sterol complexes for new ionic channels. The spectral analysis of filipin and research of its action was in parallel carried out on cell cultures infected by Influenza virus. The results of experiments confirmed literature information about action of filipin on viruses that may be prerequisite for the subsequent use of preparation as pharmaceutical.
Ключевые слова: Keywords: macrocyclic compounds, filipin, polyene antibiotics, ionic channels, hybrid ionic channels.  
Данные для цитирования: Baghirova Arifa. Institute of Botany, Azerbaijan National Academy of Sciences, . FUNCTIONAL ANALYSIS OF EXPERIMENTAL DATA IN THE FIELD OF MODERN RESEARCHES OF NEUTRAL MACROCYCLIC ANTIMYCOTIC FILIPIN.. Восточно Европейский Научный Журнал. Биологические науки. ; ():-.



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