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Дата публикации статьи в журнале: 2020/01/08
Название журнала: Восточно Европейский Научный Журнал, Выпуск: 52, Том: 2, Страницы в выпуске: 53-58
Анотация: The gastrointestinal failure syndrome (GIFS) is considered not only a composite component, but also a driving force for the formation of multiple organ lesions. The frequency of this syndrome in Neonatal Intensive Care Units is equal to 80%. A faster development of such a pathological state as intra-peritoneal hypertension, which is accompanied by deepening of splanchnic hypoperfusion and bacterial translocation. On the part of the immune system, it is advisable to emphasize its incompleteness, which promotes bacterial translocation. 113 newborns with surgical pathology, consequences of asphyxia at birth and perinatal infection, having gastrointestinal insufficiency syndrome, were examined. The clinical severity of this syndrome was established and the interleukins levels of 1, 6 and 10 in the serum of patients were determined. The increase of IL-1 content was found to be 102-fold up to 226 (113.5; 330) pg / ml (p <0.001); IL-6 - 5.5-fold up to 33.6 (24.3-156) pg / ml (p <0.001); IL-10 was 3.3-fold up to 10.4 (6.1-44.9) pg / ml (p <0.001). The increased levels of cytokine ratios in favor of pro-inflammatory interleukins were established. These ratios of interleukins were significantly higher than the control rates for clinically significant gastrointestinal insufficiency syndrome, except for the concentration of interleukin-1, which increased regardless of the clinical severity of the syndrome. It was also noted that the newborns with surgical pathology had significant interleukin feedback in favor of a pro-inflammatory response. Thus, in newborns with gastrointestinal insufficiency syndrome, there was a considerable increase in interleukins1, 6, 10, which is characteristic of the clinically pronounced manifestations of this syndrome, except for the increase in IL-1 concentration, the changes of which are nonspecific and not related to the nature of the underlying disease. Patients with surgical pathology are characterized by an increase in cytokines in favor of a proinflammatory response.
Ключевые слова: newborns gastrointestinal failure syndrome interleukins
Данные для цитирования: Kholod D.A. , Shkurupii D.A. , . CHANGES IN THE CONTENT OF PRO- AND ANTI-INFLAMMATORY CYTOKINES IN NEONATES WICH GASTROINTESTINAL FAILURE SYNDROME (53-58). Восточно Европейский Научный Журнал. Медицинские науки. 2020/01/08; 52(2):53-58.