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Дата публикации статьи в журнале: 2019/09/19
Название журнала: Восточно Европейский Научный Журнал, Выпуск:
48, Том: 3,
Страницы в выпуске: 37-48
Анотация: In this research we have investigated in 65 years old non-diabetic patients with uncomplicated arterial hypertension, the influence of two types of antihypertensive treatment based on a renin-angiotensin system inhibitor (RAS) and a dihydropyridine calcium channel blocker (CCB) ± thiazide-like diuretic (indapamide) on central and brachial blood pressure (BP) hemodynamics and in several cardiac and vascular structure-function parameters. We included 174 patients from two centers (83 males and 91 females). After 6 months a total of 158 patients finished the study. We found that amlodipine + indapamide therapy was more effective than RAS inhibitors + indapamide in reducing brachial and central systolic BP, and central pulse pressure in males. In addition, and regardless of gender, the calcium channel blocker therapy achieve a greater reduction on left ventricle pulsatile load (measured by augmentation markers), on arterial stiffness (measured by carotid-femoral pulse wave velocity) and regression of LV hypertrophy. Therapy with amlodipine plus indapamide was associated with an increase in heart rate.
Ключевые слова:
arterial pressure
arterial hypertension
arterial wall stiffness
structure-functional condition of the heart
Данные для цитирования:
Amosova Kateryna ,
Lazarieva Kateryna ,
Javier López Diaz .
GENDER SPECIFIC DIFFERENCES IN THE EFFECTS OF ANTIHYPERTENSIVE THERAPY ON ARTERIAL HEMODYNAMIC, ARTERIAL WALL STIFFNESS AND STRUCTURE-FUNCTIONAL CONDITION OF THE HEART IN PATIENTS OVER 65 YEARS OLD WITH UNCOMPLICATED ARTERIAL HYPERTENSION (37-48). Восточно Европейский Научный Журнал. Медицинские науки. 2019/09/19;
48(3):37-48.