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Дата публикации статьи в журнале: 2020/01/08
Название журнала: Восточно Европейский Научный Журнал, Выпуск:
52, Том: 2,
Страницы в выпуске: 7-16
Анотация: Introduction. In its development and course, hemangioma (HA) destroys and does not disperse surrounding tissues that causes significant functional and cosmetic damage. The widespread occurrence of HA in childhood, delayed diagnosis, unreasonable tactics, mistakes in the choice of treatment method, encourage specialists from a wide range of occupations to address constantly to this problem, which has not yet reached its final solving.
Introduction. In its development and course, hemangioma (HA) destroys but does not disperse the surrounding tissues that cause significant functional and cosmetic damages, especially if localized in "critical zones". The widespread occurrence of HA at childhood, delayed diagnosis, unjustified expectancy tactics, mistakes in choosing of the treatment method, encourages specialists from a wide range of occupations to address constantly this problem, which has not yet reached its final solving. Perhaps there is no child surgeon who would not treat HA in his practice, as there is no specialist who would not fail. [5]
The use of traditional HA therapies often does not lead to the expected result, and is sometimes accompanied by complications of the tumor surface in the form of ulcers, which are accompanied by a long course of the inflammatory process and the lack of a tendency for rapid healing of ulcers.
Aim: to study the mechanism of action and effectiveness of triamcinolone and betamethasone in the injection method for the treatment of hemangiomas at children.
Materials and methods: the results of inpatient and outpatient treatment of 117 children (81 girls and 36 boys) with external HA localization. The material for the study was blood serum, in which, before the treatment on the 7, 14 and 21 days after intra-tumor injection of a mixture of tritenolone and betamethasone the levels of acute phase inflammation proteins, namely sialic acids and seromucoids, were determined.
Results. Seromucoids level on the 7th day exceeded 4 times the value of the indicator before the beginning of treatment, respectively 0.72 ± 0.05 units of opt. density versus 0.18 ± 0.02 units of opt. density, (p <0.05), on the 14th day exceeded the value 1.78 respectively 0.32±0.04 units of opt. density versus 0.18±0.02 of opt. density (p<0.05), reaching almost normal level up to the 21st day. The level of sialic acids exceeded 1.76 times the rate before treatment, respectively, 3.52 ± 0.5 mmol / l versus 2.0 ± 0.3 mmol / l, (p <0.05), on the 14th days only 1.16 times, respectively 2.31 ± 0.4 mmol / l against 2.0 ± 0.3 mmol / l, (p> 0.05), reaching a practically normal level up to the 21st day.
Taking into account the obtained dynamics of the proteins of the acute phase of inflammation, claimed that the maximum destructive effect on the HA tissue after the injection of triamcinolone and betamethasone occurs during the first 7 days, with a gradual decreasing in the expressiveness of the effective action to the 21st day.
Conclusions. Intra-tumor administration of triamcinolone and betamethasone contributes to satisfactory cosmetic and functional results at 95.73%, which allows it to be considered as an alternative to surgical excision of the tumor, in which technical difficulties and complications can occur.
Ключевые слова:
children
hemangioma
triamcinolone
betamethasone
treatment
Данные для цитирования:
Konoplitskyi D.V. ,
Fomin O.O. ,
Dmytriiev K.D. .
MINIMALLY INVASIVE TREATMENT OF HEMANGIOMAS AT CHILDREN BY INJECTION OF TRIAMCINOLONE AND BETAMETASON (7-16). Восточно Европейский Научный Журнал. Медицинские науки. 2020/01/08;
52(2):7-16.