MORPHO-FUNCTIONAL OUTCOMES OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY COMBINED WITH 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE ADMINISTRATION ON THE SPINAL CORD ANTERIOR HORN NEURONS (18-24)

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Дата публикации статьи в журнале: 2020/06/11
Название журнала: Восточно Европейский Научный Журнал, Выпуск: 57, Том: 2, Страницы в выпуске: 18-24
Автор: Gerashchenko S.B.
, Ivano-Frankivsk National Medical University Department of Histology, Cytology and Embryol,
Автор: Deltsova O.I.
, Ivano-Frankivsk National Medical University Department of Histology, Cytology and Embryol,
Автор: Ostrovskyi M.M.
, Ivano-Frankivsk National Medical University Department of Histology, Cytology and Embryol,
Анотация: Paclitaxel-induced peripheral neuropathy (PIPN) is a major debilitating side effect of paclitaxel in patients with cancer with no fully known mechanisms. The aim of the study was to investigate the fine submicroscopic structure of the spinal cord anterior horn neurons in PIPN combined with 2-ethyl-6-methyl-3hydroxypyridine succinate administration. The experiment was performed on 80 white rats, which were administered intraperitoneally with Paclitaxel (Actavis, Romania), pre-dissolved in an isotonic saline at a dose of 2 mg / kg body weight four times a day to achieve a dose of 8 mg / kg. Then 48 of these animals were injected intraperitoneally 2-ethyl-6-methyl-3-hydroxypyridine succinate (Armadine) at a dose of 10 mg / kg (32 rats received intraperitoneally water for injection). Observation periods were 1, 7, 14, 21, 28 days. We found that 2ethyl-6-methyl-3-hydroxypyridine corrects the morpho-functional state of the motor neurons of the spinal cord and revealed a positive metabolic effect on them. This was manifested by the improvement of the electron microscopic picture of the neuronal structures responsible for their protien-synthetic (granular endoplasmic reticulum, ribosomes and polysomes), respiratory (mitochondria), and protective (lysosomes) functions.
Ключевые слова: paclitaxel   paclitaxel-induced peripheral neuropathy   spinal cord   2-ethyl-6-methyl-3- hydroxypyridine succinate  
Данные для цитирования: Gerashchenko S.B., Deltsova O.I., Ostrovskyi M.M. . MORPHO-FUNCTIONAL OUTCOMES OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY COMBINED WITH 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SUCCINATE ADMINISTRATION ON THE SPINAL CORD ANTERIOR HORN NEURONS (18-24). Восточно Европейский Научный Журнал. Медицинские науки. 2020/06/11; 57(2):18-24.

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