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Дата публикации статьи в журнале: 2020/01/08
Название журнала: Восточно Европейский Научный Журнал, Выпуск:
52, Том: 1,
Страницы в выпуске: 54-57
Анотация: The objective of the study was to investigate the possible role of the rs759853 and rs9640883 polymorphisms of the AKR1B1 gene by comparing the distribution of genotypes and alleles in the control group and in patients with type 2 diabetes mellitus and diabetic retinopathy (DR). A total of 302 patients were involved in this study, where 98 patients were in the control group; Group 1 – 76 patients with type 2 diabetes mellitus showing no visible changes in the fundus; Group 2 – 64 patients with non-proliferative DR and Group 3 – 64 patients with proliferative DR. The analysis of polymorphic loci was performed using unified TaqMan Mutation Detection Assays Thermo Fisher Scientific test systems (USA). Statistical analysis of the results of studies was performed using SPSS 11.0, Medstat, MedCalc (MedCalc SoftWare bvba, 1993-2013).
It was determined that there was a significant increase in the frequency of the G/A heterozygote of the rs759853 polymorphism in type 2 diabetes mellitus as compared to the control group, whereas the development of DR was associated with an increase in the frequency of the mutant A/A homozygote, especially in proliferative DR. In case of progressive DR, a significant decrease in the G allele frequency and an increase in the A allele frequency of the rs759853 polymorphism of the AKR1B1 gene were detected. In case of progressive DR, there were also found an increase in the G allele frequency and a decrease in the A allele frequency of the rs9640883 of the AKR1B1 gene. The homozygous genotype of the mutant A/A allele of the rs9640883 polymorphism was not detected in patients with DR at all, and this justified the idea of the protective effect of the minor A allele in the development of DR.
The study showed the role of the rs759853 and rs9640883 polymorphisms of the AKR1B1 gene. The main factors contributing to the progression of DR included the increased frequence of the A allele of rs759853 and G allele of rs9640883; the protective role was played by the A allele and A/A genotype of rs9640883
Ключевые слова:
type 2 diabetes mellitus
diabetic retinopathy
rs759853
rs9640883
AKR1B1
Данные для цитирования:
Bushuyeva O.V. ,
.
NEW FACTORS OF DIABETIC RETINOPATHY PROGRESSION IN TYPE 2 DIABETES MELLITUS PATIENTS (54-57). Восточно Европейский Научный Журнал. Медицинские науки. 2020/01/08;
52(1):54-57.