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Дата публикации статьи в журнале: 2020/05/12
Название журнала: Восточно Европейский Научный Журнал, Выпуск:
56, Том: 1,
Страницы в выпуске: 27-32
Автор: Kravets O.V.
Kyiv, Ukraine , National Cancer Institute, Head and Neck Oncology Department, Candidate of Medical Science, Senior Researcher
Kyiv, Ukraine , National Cancer Institute, Head and Neck Oncology Department, Candidate of Medical Science, Senior Researcher
Автор: Cherniienko V.V.
Kyiv, Ukraine , National Cancer Institute, Head and Neck Oncology Department, Surgeon
Kyiv, Ukraine , National Cancer Institute, Head and Neck Oncology Department, Surgeon
Автор: Burtyn O.V.
Kyiv, Ukraine , National Cancer Institute, Head and Neck Oncology Department, Surgeon
Kyiv, Ukraine , National Cancer Institute, Head and Neck Oncology Department, Surgeon
Анотация: Aim. To determine the prognostic significance of histopathological grade factor in patients with resectable advanced oral squamous cell carcinoma.
Object and methods. A retrospective analysis of the results of the treatment of 295 patients with resectable advanced oral squamous cell carcinoma was made. The analysis involved the patients who have undergone primary surgery with adjuvant radiotherapy or concomitant chemoradiation therapy.
Results. The multivariate analysis using Cox model revealed a significant impact (p=0.009) of high histopathological grade on overall survival, HR = 1.48 (95% CІ 1.10 – 1.98); and the significant impact (p=0.003) of high tumor histopathological grade on disease-free survival, HR = 1.58 (95% CІ 1.18 – 2.12). When comparing the curves of overall and disease-free survival, a statistically significant difference (p=0.001 and p<0.001, respectively, according to the logrank test) was found among the groups G1, G2, G3.
Conclusions. In our study, the high histopathological grade is an independent pathohistological factor of the poor prognosis in patients with resectable advanced oral squamous cell carcinoma. The overall and disease-free survival of patients in group G2 and group G3 was significantly lower compared to group G1. Further studies are needed to investigate the necessity for adjuvant CRT in patients with these pathological factors.
Ключевые слова:
oral squamous cell carcinoma
prognostic factor
pathohistological grade
overall survival
disease-free survival
Данные для цитирования:
Kravets O.V. ,
Cherniienko V.V. ,
Burtyn O.V. .
THE PROGNOSTIC ROLE OF HISTOPATHOLOGICAL GRADE FACTOR IN PATIENTS WITH RESECTABLE ADVANCED ORAL SQUAMOUS CELL CARCINOMA (27-32). Восточно Европейский Научный Журнал. Медицинские науки. 2020/05/12;
56(1):27-32.