VALUE OF THE PYRIDOXINE OF THE HYDROCHLORIDE AND COPPER IN PREVENTION OF ATHEROSCLEROSIS (Literary review)

Архив в PDF формате
Дата публикации статьи в журнале:
Название журнала: Восточно Европейский Научный Журнал, Выпуск: , Том: , Страницы в выпуске: -
Автор: Ochilova Dilorom Abdullayevna Associate professor of department of pharmacology, normal and pathological physiology of the Bukhara state medical institute Bukhara. Republic of Uzbekistan ORCID ID 0000-0003-0310-692X Komilova Bakhmal Odilovna Candidate of Biology, the assistant to department of pharmacology, normal and pathological physiology of the Bukhara state medical institute Bukhara. Republic of Uzbekistan ORCID ID 0000-0001-5698-3139
, ,
Анотация: Annotation: The article provides a literature review of the importance of pyridoxine hydrochloride and copper in the prevention of atherosclerosis. Vitamin B6 deficiency and absolute or relative copper deficiency are affected by a common metabolic event, namely the function of lysyl oxidase in connective tissue maturation, which may be relevant in the initial lesion of atherosclerosis. The use of pyridoxine hydrochloride and copper is highly effective in preventing atherosclerosis. Fixed combinations of copper and pyridoxine in diseases associated with atherosclerosis, and their prevention provide effective results.
Ключевые слова: Keywords: atherosclerosis, prevention of atherosclerosis, pyridoxine hydrochloride, copper (Cu) as a necessary micronutrient  
Данные для цитирования: Ochilova Dilorom Abdullayevna Associate professor of department of pharmacology, normal and pathological physiology of the Bukhara state medical institute Bukhara. Republic of Uzbekistan ORCID ID 0000-0003-0310-692X Komilova Bakhmal Odilovna Candidate of Biology, the assistant to department of pharmacology, normal and pathological physiology of the Bukhara state medical institute Bukhara. Republic of Uzbekistan ORCID ID 0000-0001-5698-3139, . VALUE OF THE PYRIDOXINE OF THE HYDROCHLORIDE AND COPPER IN PREVENTION OF ATHEROSCLEROSIS (Literary review). Восточно Европейский Научный Журнал. Медицинские науки. ; ():-.



Список литературы: Literature. 1. Алтамышев А. Лекарственные богатства Киргизии Фрунзе, Кыргызыстан 1976 2. Громова О.А., Торшин И.Ю., Назаренко А.Г., Калачева А.Г. Дефицит магния и пиридоксина как фактор риска развития ишемической болезни сердца Журнал. Кардиология, 2016.10.55-62 3. Дыдыкина И.С., Дыдыкина П.С., Алексе- ева О.Г. Вклад микроэлементов (меди, марганца, цинка, бора) в здоровье кости: вопросы профилак- тики и лечения остеопении и остеопороза- Эффек- тивная фармакотерапия 2014, 3, 34-38 4. Зеленов В.И., Цокур М.Н., Шабанова И.В. Способ получения комплексного соединения меди с пиридоксином - Государственное образователь- ное учреждение высшего профессионального обра- зования "Кубанский государственный универси- тет" (ГОУ ВПО КубГУ), Номер патента: 2415860 Россия, 2011. 5. Исламова А.И., Мифтахова Р.Н., Абдрах- манов А.С. Физиологическая роль меди и ее соеди- нений - Инновационный потенциал молодежной науки - Материалы Всероссийской научной конфе- ренции 8 ноября 2013 г.–Уфа 2013, 115-118. 6. Кароматов И.Д. Простые лекарственные средства Бухара 2012 7. Кароматов И.Д. Медь и его значение в ме- дицине Электронный научный журнал «Биология и интегративная медицина» 2017 №11 8. Мифтахова Р.Н., Исламова А.И., Абдрах- манов А.С.Лечебные свойства меди и ее соедине- ний - Инновационный потенциал молодежной науки - Материалы Всероссийской научной конфе- ренции 8 ноября 2013 г.–Уфа 2013, 176-179 9. Нормы физиологических потребностей в энергии и пищевых веществах для различных групп населения Российской Федерации. Методические рекомендации МР 2.3.1.2432-8 // 10. Павлова О.С. Современные возможности эффективной сердечно–сосудистой профилактики у пациентов с артериальной гипертензией и дисли- пидемией. Мед, новости. 2012; 1: 62–68. 11. Часова Э.В., В.В. Ивчук. Некоторые ас- пекты токсического воздействия тяжелых металлов на организм человека. Материалы ІІ молодежной международной научно-практической конферен- ции студентов, аспирантов, и молодых ученых «Наука ХХІ века: новый подход». – Санкт-Петер- бург, 28 сентября 2012 года. – С. 32-38 12. Persicov А.V., Brodsky B. Unstable mole- cules form stable tissues // Proc. Natl. Acad. Sci. USA. 2002. Vol. 99. № 3. P. 1101–1103. 13. Opsahl W., Zeronian H., Ellison M. et al. Role of copper in collagen cross-linking and its influence on selected mechanical properties of chick bone and ten- don // J. Nutr. 1982. Vol. 112. № 4. P. 708–716. 14. Endo N., Nishiyama K., Okabe M., Matsumoto M., Kanouchi H., Oka T. Vitamin B6 suppresses apoptosis of NM-1 bovine endothelial cells induced by homocysteine and copper. Biochim Biophys Acta. 2007 Apr;1770(4):571-577. 15. Klevay, L.M.Allen, Vitamin B6, copper, and atherosclerosis. The lancet 1977. 16. Fukai T., Ushio-Fukai M., Kaplan J.H. Copper transporters and copper chaperones: roles in cardiovas- cular physiology and disease - Am J. Physiol Cell Phys- iol. C186-C201. doi: 10.1152/ajpcell.00132.2018. 2018, Jun 6. 17. Gao W., Sun Y., Cai M., Zhao Y., Cao W., Liu Z., Cui G., Tang B. Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis - Nat. Commun. 2018, Jan 15, 9(1), 231. doi: 10.1038/s41467-017-02657-z. 18. Bayrak A., Bayrak T., Bodur E., Kılınç K., Demirpençe E. The effect of HDL-bound and free PON1 on copper-induced LDL oxidation-Chem Biol Interact. 2016,25,141-146. doi: 10.1016/j.cbi.2016.08.007. 19. Klevay L., M. IHD from copper deficiency: a unified theory- Nutr Res Rev. 2016, 29,172-179. 20. Seo Y., Cho Y., Huh Y., Park H. Copper Ion from Cu2O Crystal Induces AMPK-Mediated Autoph- agy via Superoxide in Endothelial Cells-Mol Cells. 2016, 39, 195-203. doi: 10.14348/molcells.2016.2198. 21. Tasić N., Tasić D., Otašević P., Veselinović M., Jakovljević V., Djurić D., Radak D. Copper and zinc concentrations in atherosclerotic plaque and serum in relation to lipid metabolism in patients with carotid atherosclerosis- Vojnosanit Pregl. 2015,72,801-806. 22. Bagheri B., Akbari N., Tabiban S., Habibi V., Mokhberi V. Serum level of copper in patients with coronary artery disease. Niger Med J. 2015,56,39-42. doi: 10.4103/0300-1652.149169. 23. Zimnicka A., Tang H., Guo Q., Kuhr F., Oh M., Wan J., Chen J., Smith K., Fraidenburg D., Choudhury M., Levitan I., Machado R., Kaplan J., Yuan J. Upregulated copper transporters in hypoxia-in- duced pulmonary hypertension-PLoS One. 2014, 10, doi: 10.1371/journal.pone.0090544. 24. Grammer T., Kleber M., Silbernagel G., Pilz S., Scharnagl H., Lerchbaum E., Tomaschitz A., Koenig W., März W. Copper, ceruloplasmin, and long- term cardiovascular and total mortality (the Ludwigs- hafen Risk and Cardiovascular Health Study)- Free Radic Res. 2014, 48, 706-715. doi: 10.3109/10715762.2014.901510. 25. Wei H., Zhang W., Leboeuf R., Frei B. Copper induces--and copper chelation by tetrathiomolybdate inhibits--endothelial activation in vitro-Redox Rep. 2014, 19, 40-48. doi: 10.1179/1351000213Y.0000000070. 26. Wei H., Zhang W., McMillen T., Leboeuf R., Frei B. Copper chelation by tetrathiomolybdate inhibits vascular inflammation and atherosclerotic lesion devel-opment in apolipoprotein E-deficient mice - Athero- sclerosis. 2012, 223(2),306-313. doi: 10.1016/j.atherosclerosis.2012.06.013. 27. Islamoglu Y., Evliyaoglu O., Tekbas E., Cil H., Elbey M., Atilgan Z., Kaya H., Bilik Z., Akyuz A., Alan S. The relationship between serum levels of Zn and Cu and severity of coronary atherosclerosis- Biol Trace Elem Res. 2011, 144, 436-444. doi: 10.1007/s12011-011-9123-9. 28. Torshin I., Gromova O. Magnesium: funda- mental studies and clinical practice. Nova Biomedical Publishers. NY, 2011. 29. Rimm E.B., Willett W.C., Hu F.B. et al. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA 1998;279(5):359–364. 30. van Dijk R.A., Rauwerda J.A., Steyn M. et al. Long-term homocysteine lowering treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with improved brachial artery endothe- liumdependent vasodilation or carotid artery stiffness: a 2-year, randomized,placebo-control Arterioscler Thromb Vasc Biol 2001;21(12):2072–2079. 31. Кomarov F.I., Novikov V.S., Onikienko B.A. Effect of vitamin B6 on diuresis in patients with marked circulatory disorders. Kardiologiia.1964;4:53–55. PMID: 1417978140. 32. Martinez M., Cuskelly G.J., Williamson J. et al. Vitamin B-6 deficiency in rats reduces hepatic ser- ine hydroxymethyltransferase and cystathionine beta- synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration. J Nutr 2000;130(5):1115–1123. 33. Ambrosch A., Dierkes J., Lobmann R. et al. Relation between homocysteinaemia and diabetic neu- ropathy in patients with Type 2 diabetes mellitus. Dia- bet Med 2001;18(3):185–192. 34. Midttun O., Hustad S., Schneede J. et al. Plasma vitamin B-6 forms and their relation to transsul- furation metabolites in a large, population-based study. Am J Clin Nutr 2007;86(1):131–138. 35. Shen J., Lai C.Q., Mattei J. et al. Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Bos- ton Puerto Rican Health Study. Am J Clin Nutr 2010;91(2):337–342. 36. Morris M.S., Sakakeeny L., Jacques P.F. et al. Vitamin B-6 intake is inversely related to, and the re- quirement is affected by, inflammation status. J Nutr 2010;140(1):103–110. 37. Abraham P.M., Kuruvilla K.P., Mathew J., Malat A., Joy S., Paulose C.S. Alterations in hippocam- pal serotonergic and INSR function in streptozotocin induced diabetic rats exposed to stress: neuroprotective role of pyridoxine and Aegle marmelose. J. Biomed. Sci. 2010; 17:78. 38. Okada M., Shibuya M., Yamamoto E., Mura- kami Y. Effect of diabetes on vitamin B6 requirement in experimental animals. Diabetes Obes. Metab. 1999; 1(4):221–225. 39. Kiran S.G., Dorisetty R.K., Umrani M.R., Boindala S., Bhonde R.R., Chalsani M., Singh H., Ven- katesan V. Pyridoxal 5’ phosphate protects islets against streptozotocin-induced beta-cell dysfunction-- in vitro and in vivo. Exp. Biol. Med (Maywood). 2011;236(4):456–465. 40. Sharafetdinov Kh.Kh., Plotnikova O.A., Meshcheriakova V.A., Kodentsova V.M., Vrzhesin- skaia O.A., Spirichev V.B., Shatniuk L.N. Vitamin sup- ply in patients with non-insulin-dependent diabetes mellitus. Klin. Med. (Mosk). 1999;77(4):26–8 (in Russ.)] 41. Spellacy W.N., Buhi W.C., Birk S.A. Vitamin B6 treatment of gestational diabetes mellitus: studies of blood glucose and plasma insulin. Am. J. Obstet. Gy- necol. 1977;127(6):599–602. 42. Bennink H.J., Schreurs W.H. Improvement of oral glucose tolerance in gestational diabetes by pyri- doxine. Br. Med. J. 1975;3(5974):13–15. 43. Stehouwer C.D., van Guldener C. Does ho- mocysteine cause hypertension? Clin. Chem. Lab. Med. 2003;41(11):1408–1411.